2014 – Parasomnias and isolated sleep symptoms in Parkinson’s disease

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Parasomnias and isolated sleep symptoms in Parkinson’s disease: A questionnaire study on 661 patients

Authors: Ari Ylikoski, Kirsti Martikainen, Markku Partinen
Date: 2014
Link: https://doi.org/10.1016/j.jns.2014.08.025

Highlights

  • Occurrence of parasomnias was studied in 661 patients with Parkinson’s disease (PD).
  • Parasomnias and isolated sleep symptoms are frequent in patients with PD.
  • In PD patients, sleepwalking is highly associated with REM behavior disorder (RBD).
  • If a PD patient has sleepwalking, nightmares or sleep talking, RBD may be present.

Abstract

Background

Sleep disorders are among the most common non-motor symptoms in Parkinson’s disease.

Method

The prevalence of parasomnias and their association with other symptoms were studied in a questionnaire study among 1447 randomly selected Parkinson patients, aged 43 to 89 years. The response rate was 59.0% and of these 77% had answered to all questions that were used in the analyses ( N = 661).

Results

The prevalence of REM sleep behavior disorder (RBD) evaluated by the RBDSQ ≥ 6 was 39.0%. The occurrences of other parasomnias (≥ 1/week) in patients with PD were: nightmares 17.2%, night terrors 3.9%, sleepwalking 1.8%, enuresis 21.0%, and hallucinations 15.3%. Occurrences (≥ 1/week) of the isolated sleep symptoms were: nocturnal sweating 28.8%, bruxism 4.7%, and sleep talking 21.7%. Association of RBD with sleepwalking (parasomnia overlap disorder) was found in 1.7% of all PD patients. Adjusted logistic regression analysis showed that weekly nightmares (OR 12.5; 95% CI 5.3 to 29.7), hallucinations (OR 5.1; 2.1 to 12.4), sleep talking (OR 11.6; 5.9 to 22.8), male gender (OR 1.9; 1.1 to 3.1), and restless legs syndrome (OR 4.7; 1.7 to 13.2) associated with the presence of RBD.

Conclusion

Parkinson patients with RBD have often also other parasomnias and/or isolated sleep symptoms.

Keywords

Parkinson’s disease, Sleep ,RBD, Other parasomnias, Isolated sleep symptoms

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